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M9650505.TXT
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1996-03-09
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Document 0505
DOCN M9650505
TI [Intra-family transmission of human T-cell lymphotropic virus-1 (HTLV-1)
in a cohort of HTLV-1-positive patients (Benin)]
DT 9605
AU Houinato D; Verdier M; Josse R; Foundohou J; Preux PM; Avode G; Zohoun
T; Denis F; Dumas M; Institut d'Epidemiologie neurologique et de
neurologie; tropicale, Limoges.
SO Bull Soc Pathol Exot. 1995;88(3):79-80. Unique Identifier : AIDSLINE
MED/96150674
AB We are reporting the results of a familial study carried out in Benin in
March 1994 within a cohort of HTLV-1 positive subjects. This study aims
at appraising the different modes of intra-familial transmission of this
retrovirus. The study has included 212 persons: 33 seropositive subjects
(identified during two previous seroprevalence surveys and followed up
since 1991), and 179 members of their families. Blood specimens have
been taken from each of these subjects. Sera have been screened for
HTLV-1 antibodies by ELISA test and positive results confirmed by
Western blot test. Out of 18 children born during the follow up period,
2 cases of seroconversion have been observed. One case of seroconversion
has also been noted among the 17 couples in which either of the spouses
is seropositive. Among the 136 children of the cohort: 17.8% of them are
HTLV-1 positive when both parents are seropositive 26.1% if the mother
only is seropositive and 0% if the father only is seropositive. The
incidence rate in this cohort is estimated to be 0.43%. These data
relative to the intra-familial transmission of HTLV-1 in Benin appear to
be consistent with those previously reported in Japan.
DE Benin Blotting, Western Child Cohort Studies *Disease Transmission,
Vertical English Abstract Enzyme-Linked Immunosorbent Assay Fathers
Female Follow-Up Studies Human HTLV-I/ISOLATION & PURIF HTLV-I
Antibodies/BLOOD HTLV-I Infections/GENETICS/*TRANSMISSION Incidence
Male Mothers Seroepidemiologic Methods JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).